Messina - Wikipedia WebMessina (/ m ɛ ˈ s iː n ə /, also US: / m ɪ ˈ-/, Italian: [mesˈsiːna] ()) is a harbour city and the capital of the Italian Metropolitan City of Messina.It is the third largest city on the island of Sicily, and the 13th largest city in Italy, with a population of more than 219,000 inhabitants in the city proper and about 650,000 in the Metropolitan City.